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. 2019 Sep 25;9:13854. doi: 10.1038/s41598-019-50435-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alleviation of resorption of subchondral bone by hUCM-MSCs. (a) Subchondral bone destruction as shown via micro-CT imaging. The surface of the bone in the MSC-treated groups was not significantly different from that in the control group; however, lesions are visible in the untreated TMJ-OA-induced and Dex-treated groups (red arrows and circle). Scale bar = 1 mm. (b) Enlarged comparison picture of Dex-treated and MSC-treated groups. micro-CT: micro-computed tomography; DEX: dexamethasone; MSCs: mesenchymal stem cells, RT-PCR: reverse transcription polymerase chain reaction; micro-CT: micro-computed tomography.