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. 2019 Sep 25;10:4359. doi: 10.1038/s41467-019-12328-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Genes positively regulated by BDR proteins tend to have highly expressed upstream neighbors on the same strand. a Fraction of BDR-regulated genes that have upstream or downstream neighbors at various orientations, within the indicated distances. b BDR-protected genes and their upstream tandem neighbors have short intergenic distances. Distribution of intergenic distances between tandem genes. Distribution differences relative to all genes were evaluated by Kolmogorov–Smirnov test with BH correction. c The upstream tandem neighbors of BDR-protected genes have relatively high expression levels. Wild-type gene expression levels for upstream tandem neighbors from the indicated groups of genes (left panel). Differences are evaluated by Mann–Whitney U test. Right panel, gene ontology analysis (goseq R package) of the upstream tandem neighbors of BDR-protected genes. Categories with p < 0.001 are shown. The centerline of the boxplot is the median. The bounds of the box are the first and third quartiles (Q1 and Q3). Whiskers represent data range but are bounded to 1.5-fold the interquartile range (Q3–Q1); points outside this range are represented individually