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. 2019 Sep 25;9:13892. doi: 10.1038/s41598-019-50456-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the unusual integrative conjugative element ICEKp2 of K. pneumoniae HS11286 with PFGI1 of Pseudomonas fluorescens Pf-5 classifed ICEKp2 as a member of the PAPI family. ICEKp2 contains sufficient predicted ORFS for mobilisation: recombination, DNA segregation, and conjugation (T4SS and relaxase), plus 28 cargo genes. Homology and synteny of the mobilisation genes place it in the PAPI family. Predicted open reading frames (ORFs) are shaded according to their putative functions (ORFs are listed in table S1). Black triangles on ICEKp2 boundaries represent the direct repeat sequences for chromosomal integration to generate attL and attR sites. Further information on the annotation of ORFs is provided in Table S1. Blue shading represents the regions of synteny of DNA mobilisation and integration modules between ICEKp2 and PFGI-1 and PAPI of other Pseudomonas spp.^18,66.