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. 2019 Sep 25;9:13845. doi: 10.1038/s41598-019-49970-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AUC computed for CN versus AD (A), eMCI versus lMCI (B) comparisons with the different considered biomarkers in each hippocampal area. Results of subfields are grouped by features (i.e., the volume, the average of MD and the MPBG). Upper bounds of the confidence interval are represented with vertical bars. Whole hippocampus volume biomarker provides the best results with a mean AUC of 86.6% for CN versus AD comparison, followed by the CA1S-R-L-M volume that obtains a mean AUC of 86%. Subiculum volume provides the best results for eMCI versus lMCI with a mean AUC of 66.1%. The average of MD for subiculum obtains the best results for CN versus AD and eMCI versus lMCI with a mean AUC of 88.1% and 62.4%, respectively. Whole hippocampus MPBG obtains the best results for CN versus AD with a mean AUC of 92.1%. Subiculum MPBG obtains the best results for eMCI versus lMCI comparison with a mean AUC of 71.8%. This comparison shows that subiculum is the only biomarker providing better results than the whole hippocampus. This figure presents mean AUC and the mean confidence intervals that have been computed for each iteration of the stratified 5-fold cross-validation procedure carried out in our experiments.