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. 2019 Sep 25;9:13905. doi: 10.1038/s41598-019-50307-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Data from in vivo and in vitro studies using MMC indicate that corneal epithelial cells play key roles in regulating regenerative wound repair in the cornea. In vivo studies have shown that a single prophylactic treatment of MMC enhances regenerative wound repair and RNAseq studies show that epithelial cells upregulate mRNAs for SASP proteins^19,20. Our in vitro studies show that corneal epithelial cells also respond to MMC by upregulating SASP proteins and these proteins are capable of suppressing TGFβ1 induced matrix deposition by corneal fibroblasts. Taken together, these data indicate that corneal epithelial cells as well as corneal fibroblasts play important roles in regulating regenerative, non-scarring, repair of the cornea after injury. SOC = standard of care. SASP = senescence associated secretory proteins.