Table 4.
mRNA expression levels of S1P-related genes involved in S1P pathway in heart failure and control hearts.
| Gene name | Description | Function | Heart failure hearts (n=26) | Control hearts (n=10) | p-value |
|---|---|---|---|---|---|
| S1PR1 | Sphingosine 1-phosphate receptor 1 | S1P receptor activity | 480 ± 126 | 574 ± 393 | 0.474 |
| S1PR2 | Sphingosine 1-phosphate receptor 2 | S1P receptor activity | 1.83 ± 1.86 | 5.02 ± 8.74 | 0.271 |
| S1PR3 | Sphingosine 1-phosphate receptor 3 | S1P receptor activity | 80 ± 40 | 143 ± 77 | 0.033 |
| S1PR4 | Sphingosine 1-phosphate receptor 4 | S1P receptor activity | 2.17 ± 2.01 | 3.60 ± 5.32 | 0.431 |
| S1PR5 | Sphingosine 1-phosphate receptor 5 | S1P receptor activity | 3.18 ± 3.02 | 2.65 ± 3.46 | 0.653 |
| SPHK1 | Sphingosine kinase 1 | S1P generation | 30 ± 16 | 36 ± 31 | 0.562 |
| SPHK2 | Sphingosine kinase 2 | S1P generation | 40 ± 16 | 32 ± 14 | 0.214 |
| SGPP1 | Sphingosine-1-phosphate phosphatase 1 | S1P dephosphorylation | 41 ± 14 | 61 ± 39 | 0.045 |
| SGPP2 | Sphingosine-1-phosphate phosphatase 2 | S1P dephosphorylation | 16 ± 13 | 45 ± 31 | 0.016 |
| SGPL1 | Sphingosine-1-phosphate lyase 1 | S1P breakdown | 160 ± 53 | 172 ± 65 | 0.586 |
Data are showed as the mRNA expression levels (arbitrary units) ± standard deviation.