Table 2.
Cumulative live birth rates according to the POSEIDON stratification.
| Cycle | Number of patients | Live birth, n (%) | CLBR across all cycles (%) | |
|---|---|---|---|---|
| Optimal estimatea | Conservative estimateb | |||
| POSEIDON GROUP 1 | ||||
| First cycle | 12,040 | 6,747 (56.04) | 56.04 | 56.04 |
| Second cycle | 2,452 | 1,123 (45.80) | 76.17 | 65.37 |
| Third cycle | 277 | 84 (30.32) | 83.87 | 66.06 |
| Fourth cycle | 32 | 5 (15.63) | 86.39 | 66.10 |
| Fifth cycle | 6 | 3 (50.00) | 93.20 | 66.13 |
| ≥Sixth cycle | 1 | 0 (0) | 93.20 | 66.13 |
| POSEIDON GROUP 2 | ||||
| First cycle | 4,849 | 1,496 (30.85) | 30.85 | 30.85 |
| Second cycle | 1,299 | 301 (23.17) | 46.87 | 37.06 |
| Third cycle | 250 | 32 (12.80) | 53.67 | 37.72 |
| Fourth cycle | 64 | 9 (14.06) | 60.17 | 37.90 |
| Fifth cycle | 19 | 0 (0) | 60.17 | 37.90 |
| ≥Sixth cycle | 9 | 0 (0) | 60.17 | 37.90 |
| POSEIDON GROUP 3 | ||||
| First cycle | 672 | 99 (14.73) | 14.73 | 14.73 |
| Second cycle | 331 | 63 (19.03) | 30.91 | 24.11 |
| Third cycle | 135 | 26 (19.26) | 44.24 | 27.98 |
| Fourth cycle | 51 | 11 (21.57) | 56.29 | 29.61 |
| Fifth cycle | 24 | 1 (4.17) | 58.12 | 29.76 |
| ≥Sixth cycle | 16 | 0 (0) | 58.12 | 29.76 |
| POSEIDON GROUP 4 | ||||
| First cycle | 2,220 | 146 (6.58) | 6.58 | 6.58 |
| Second cycle | 1,062 | 55 (5.18) | 11.46 | 9.05 |
| Third cycle | 457 | 14 (3.06) | 14.20 | 9.68 |
| Fourth cycle | 202 | 11 (5.45) | 18.83 | 10.18 |
| Fifth cycle | 94 | 3 (3.19) | 21.43 | 10.32 |
| ≥Sixth cycle | 53 | 4 (7.55) | 25.91 | 10.50 |
Data are shown as number of patients and percentages. CLBR, cumulative live-birth rate.
a
The optimal estimate assumes that the CLBR in women who discontinue assisted reproductive technology treatment without live-birth would be equal to the rate in those who continue.
b
The conservative estimate assumes that those who discontinue assisted reproductive technology treatment would have had a live-birth rate of zero.