Table 3.
Logistic regression based on the occurrence of live birth in the first stimulation cycle.
| Variable | Non-live birth (n = 11,293) | Live birth (n = 8,488) | Univariable logistic regression | Multivariable logistic regression | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |||
| Grouping, n (%) | ||||||
| POSEIDON group 1 | 5,293 (43.96) | 6,747 (56.04) | Reference | Reference | ||
| POSEIDON group 2 | 3,353 (69.15) | 1,496 (30.85) | 2.857 (2.662, 3.067) | <0.001 | 2.319 (2.131, 2.525) | <0.001 |
| POSEIDON group 3 | 573 (85.27) | 99 (14.73) | 7.378 (5.943, 9.16) | <0.001 | 1.356 (1.005, 1.828) | 0.046 |
| POSEIDON group 4 | 2,074 (93.42) | 146 (6.58) | 18.104 (15.249, 21.493) | <0.001 | 3.525 (2.774, 4.479) | <0.001 |
| Baseline FSH, mean ± SD | 7.37 ± 3.89 | 6.3 ± 2.36 | 1.150 (1.136, 1.165) | <0.001 | 1.017 (1.0, 1.034) | 0.053 |
| Baseline LH, mean ± SD | 4.01 ± 2.56 | 4.28 ± 2.79 | 0.962 (0.952, 0.973) | <0.001 | 0.979 (0.965, 0.993) | 0.003 |
| Baseline E2, mean ± SD | 42.8 ± 45.87 | 37.83 ± 25.61 | 1.006 (1.005, 1.007) | <0.001 | 1.002 (1.001, 1.004) | 0.001 |
| BMI, n (%) | ||||||
| <18.5 | 757 (6.70) | 719 (8.47) | 0.786 (0.706, 0.875) | <0.001 | 1.014 (0.891, 1.154) | 0.831 |
| 18.5–25 | 8,759 (77.56) | 6,540 (77.05) | Reference | Reference | ||
| >25 | 1,777 (15.74) | 1,229 (14.48) | 1.080 (0.997, 1.169) | 0.059 | 1.033 (0.938, 1.138) | 0.505 |
| Duration of infertility, mean ± SD | 5.57 ± 4.47 | 4.42 ± 3.25 | 1.079 (1.071, 1.088) | <0.001 | 1.023 (1.013, 1.033) | <0.001 |
| Cause of infertility, n (%) | ||||||
| Tubal cause | 10,309 (91.29) | 7,762 (91.45) | 0.98 (0.886, 1.083) | 0.692 | ||
| Ovulation disorder | 58 (0.51) | 83 (0.98) | 0.523 (0.373, 0.732) | <0.001 | 1.049 (0.722, 1.524) | 0.803 |
| Endometriosis | 1,078 (9.55) | 777 (9.15) | 1.047 (0.95, 1.154) | 0.351 | ||
| Male cause | 3,368 (29.82) | 2,816 (33.18) | 0.856 (0.806, 0.909) | <0.001 | 0.991 (0.920, 1.068) | 0.817 |
| Others | 193 (1.71) | 133 (1.57) | 1.092 (0.874, 1.364) | 0.44 | ||
| Multiple causes | 10,911 (96.62) | 8,279 (97.54) | 0.721 (0.608, 0.856) | <0.001 | 0.932 (0.758, 1.146) | 0.502 |
| Method of fertilization, n (%) | ||||||
| IVF | 8,853 (78.39) | 6,712 (79.08) | Reference | |||
| ICSI | 2,440 (21.61) | 1,776 (20.92) | 1.042 (0.972, 1.116) | 0.247 | ||
| Ovarian stimulation protocol, n (%) | ||||||
| Long GnRH agonist protocol | 7,192 (63.69) | 7,773 (91.58) | Reference | Reference | ||
| GnRH antagonist protocol | 2,630 (23.29) | 653 (7.69) | 4.353 (3.972, 4.77) | <0.001 | 1.856 (1.640, 2.100) | <0.001 |
| Others | 1,471 (13.03) | 62 (0.73) | 25.642 (19.848, 33.128) | <0.001 | 1.651 (1.155, 2.361) | 0.006 |
| Fresh embryo/frozen embryo, n (%) | ||||||
| Fresh embryo transfer | 7,510 (66.50) | 6,927 (81.61) | Reference | Reference | ||
| Fresh and frozen embryo transfer | 3,783 (33.50) | 1,561 (18.39) | 2.235 (2.089, 2.39) | <0.001 | 2.772 (2.567, 2.993) | <0.001 |
| Number of embryos transferred, n (%) | ||||||
| 0 | 3,998 (35.4) | 0 (0) | >999.999 (0, >999.999) | 0.903 | >999.999 (0, >999.999) | 0.973 |
| 1 | 1,938 (17.16) | 945 (11.13) | Reference | Reference | ||
| 2 | 5,296 (46.9) | 7,503 (88.4) | 0.344 (0.316, 0.375) | <0.001 | 0.514 (0.468, 0.565) | <0.001 |
| 3 | 61 (0.54) | 40 (0.47) | 0.744 (0.495, 1.116) | 0.153 | 0.747 (0.483, 1.155) | 0.190 |
Data are shown as number of patients (percentage) or mean ± SD. OR, odd ratio; CI, confidence interval; BMI, body mass index; FSH, follicular-stimulating hormone; SD, standard deviation; LH, luteinizing hormone; E2, estradiol; P: progesterone; PRL, prolactin; AMH, anti-Müllerian hormone; AFC, antral follicular count; OHSS, ovarian hyperstimulation syndrome; GnRH, gonadotropin-releasing hormone; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection.