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. 2019 Sep 19;10:603. doi: 10.3389/fendo.2019.00603

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Copyright © 2019 Wang, Zhu, Yuan, Wen, Liu, Wang, Qu, Li, Liu, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR4 and GSDMD were increased in renal tubules of DKD patients. (A) PASM staining in renal biopsy specimens of patients with Non-DKD(N-DKD) (a) and DKD (b) (arrow indicates focal tubular atrophy and interstitial fibrosis) (magnification ×200). Immunohistochemistry staining demonstrated the expression of TLR4 in renal biopsy tissues of patients with DKD (d) vs. N-DKD (c), and expressions of GSDMD in renal biopsy tissues of patients with DKD (f) versus N-DKD (e). (B–D) Blood glucose, eGFR levels, and IFTA scores in DKD and NDKD patients. Values are means ± SEM. *P < 0.05, ^#P < 0.01.