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. 2019 Sep 19;9:330. doi: 10.3389/fcimb.2019.00330

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Copyright © 2019 Conceição-Silva and Morgado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macroscopic and microscopic aspects of active lesion and scar of American Tegumentary Leishmaniasis. (A) Active lesion—single ulcer with elevated borders and granulomatous aspect in center. (B) Scar—atrophic scar after successful treatment. (C) Several amastigotes detected by immunohistochemistry (arrows) involved by a granulomatous reaction in an active lesion. (D) Two amastigotes (arrow) detected by immunohistochemistry near a discrete inflammatory reaction characterized by cell niches in a scar. Magnification bar = 10 μm.