TABLE 1.

Analysis of S1R mutants in residues potentially involved in ligand binding.

S1R residue/mutation tested	Importance of original residue for ligand binding [data summarized by Ossa et al. (2017)]	Predicted importance of residue for S1R ligand docking in crystal structure	Importance of residue for rescue of PS1-KI mushroom spines by pridopidine
W89A	N/A	+++	+++
Y103A	+++	+++	+++
L105W	+	N/A	+++
F107A	+++	+++	+++
R119A	+++	−	+++
Y120A	+	+++	+++
W121A	−	−	−
I124A	N/A	+++	+++
D126A	+++	+++	+++
D164A	N/A	+	−
E172D	+++	+++	+++
I178A	N/A	−	−

+++, important; +, moderately important; −, not important; N/A, data not available.