Table 1.
Biochemical characteristics of patients with hepatitis B virus-related liver cirrhosis with and without high-risk varices
| Variable | Without high-risk varices (n = 105) | With high-risk varices (n = 27) | P-value |
| Age | 46.32 ± 11.83 | 46.74 ± 11.17 | 0.8691 |
| Male | 88 (83.81) | 25 (92.59) | 0.2462 |
| BMI (kg/m2) | 24.6 ± 3.53 | 23.8 ± 2.96 | 0.9121 |
| HBeAg: Positive | 59 (56.19) | 11 (40.74) | 0.1512 |
| HBV DNA (log 10, copies/mL) | 6.27 ± 1.43 | 5.08 ± 1.46 | 0.0021 |
| Na+ (mmol/L) | 137.56 ± 13.80 | 139.12 ± 3.07 | 0.5601 |
| ALT (U/L) | 177.0 (64.0-318.0) | 54.0 (33.0-92.0) | 0.0003 |
| AST (U/L) | 144.0 (55.5-266.5) | 60.0 (37.0-136.9) | 0.0013 |
| GGT (U/L) | 105.0 (68.4-198.0) | 60.0 (35.0-93.0) | 0.0003 |
| TBil (μmol/L) | 24.4 (16.75-37.5) | 27.8 (15.5-48.2) | 0.6763 |
| ALB (g/L) | 37.35 ± 5.74 | 36.07 ± 5.74 | 0.3051 |
| GLB (g/L) | 31.4 (28.55-35.65) | 34.6 (28.6-39.1) | 0.1013 |
| AFP (ng/mL) | 16.47 (6.66-74.73) | 13.6 (7.00-30.1) | 0.4223 |
| BUN (mmol/L) | 4.64 ± 1.28 | 4.71 ± 1.29 | 0.8011 |
| Cr (μmol/L) | 73.0 (62.0-80.5) | 73.0 (69.0-90.0) | 0.2773 |
| PT (s) | 13.0 (11.8-14.4) | 15.4 (12.5-16.3) | 0.0023 |
| INR | 1.08 (0.98-1.17) | 1.23 (1.04-1.38) | 0.0033 |
| PTA (%) | 85.05 ± 21.33 | 74.52 ± 20.25 | 0.0221 |
| WBC (109/L) | 4.21 (3.28-5.34) | 3.64 (2.68-4.50) | 0.0523 |
| PLT (109/L) | 98.35 ± 46.49 | 67.00 ± 28.29 | 0.0001 |
| LSM (kPa) | 28.93 ± 12.41 | 35.42 ± 14.44 | 0.0211 |
| Child-Pugh score | 5.00 (5.00-7.00) | 6.00 (5.00-7.00) | 0.5083 |
| MELD | 8.83 (7.50-11.76) | 11.33 (8.81-13.18) | 0.0253 |
Data are presented as the mean ± SD, or median (interquartile range).
t-test results;
Chi square test results;
Mann–Whitney U test results.
P < 0.05 was statistically significant. AFP: Alpha-fetoprotein; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; BUN: Urea nitrogen; Cr: Creatinine; GGT: Glutamine transpeptidase; GLB: Globulin; HBeAg: Hepatitis B e-antigen; HBV DNA: Hepatitis B virus DNA; INR: International normalized ratio; LSM: Liver stiffness measurement; MELD: Model for End-Stage Liver Disease; Na+: Sodium; PLT: Platelet; PT: Prothrombin time; PTA: Prothrombin activity; TBil: Total bilirubin; WBC: White blood cell.