Table 1.
Incidence of de novo malignancies in adult orthotopic liver transplant patients
|
Number and % incidence of de novo malignancy types in all orthotopic liver transplant recipients |
||||||||||||||
| Author | Yr | Number of patients | Number of DNM | PTLD | Skin and Kaposi | Head and Neck | Lung | Renal | Colon | Prostate | Breast | Gynecological | Others | |
| Jonas et al[72] | 1997 | 458 | 33 | 7 (1.5) | 8 (1.7) | 2 (0.4) | 3 (0.7) | 0 | 0 | 0 | 3 (0.7) | 7 (1.5) | 3 (0.6) | |
| Jain et al[134] | 1998 | 1000 | 57 | NA | 24 (2.4) | 7 (0.7) | 8 (0.8) | 2 (0.2) | 4 (0.4) | 3 (0.3) | 3 (0.3) | 0 | 6 (0.6) | |
| Kelly et al[135] | 1998 | 888 | 31 | NA | 8 (0.9) | 6 (0.7) | 1 (0.1) | 0 | 3 (0.3) | 0 | 2 (0.2) | 1 (0.1) | 10 (1.1) | |
| Jimenez et al[136] | 2002 | 505 | 62 | 13 (2.6) | 16 (3.2) | 10 (2.0) | 6 (1.2) | NA | NA | NA | NA | NA | 17 (3.3) | |
| Saigal et al[73] | 2002 | 1140 | 30 | NA | 14 (1.2) | 3 (0.3) | 0 | 3 (0.3) | 1 (0.1) | 0 | 2 (0.2) | 1 (0.1) | 6 (0.5) | |
| Sanchez et al[137] | 2002 | 1421 | 125 | 35 (2.5) | 42 (3.0) | 4 (0.3) | 11 (0.8) | 3 (0.2) | 9 (0.6) | 0 | 7 (0.5) | 2 (0.1) | 13 (0.8) | |
| Benlloch et al[17] | 2004 | 772 | 41 | 10 (1.3) | NA | 9 (1.2) | 8 (1.0) | 3 (0.4) | 2 (0.3) | 1 (0.1) | 2 (0.3) | 2 (0.3) | 4 (0.5) | |
| Oo et al[138] | 2005 | 1778 | 141 | 18 (1.0) | 51 (2.9) | NA | 14 (0.8) | NA | 18 (1.0) | NA | 11 (0.6) | 1 (0.06) | 28 (1.6) | |
| Yao et al[12] | 2006 | 1043 | 53 | 9 (0.9) | 17 (0.6) | 3 (0.3) | 5 (0.5) | 2 (0.2) | 6 (0.6) | 0 | 4 (0.4) | 2 (0.2) | 5 (0.5) | |
| Aberg et al[81] | 2008 | 540 | 39 | 9 (1.7) | 11 (2.0) | 2 (0.3) | NA | 2 (0.3) | 2 (0.3) | 2 (0.3) | 1 (0.1) | NA | 10 (1.8) | |
| Jiang et al[20] | 2008 | 2034 | 113 | 44 (2.1) | NA | 3 (0.1) | 10 (0.5) | 4 (0.2) | 14 (0.7) | 5 (0.2) | 5 (0.2) | NA | 24 (1.2) | |
| Baccarani et al[139] | 2010 | 417 | 43 | 9 (2.1) | 8 (1.9) | 8 (1.9) | 4 (0.9) | 0 | 2 (0.5) | 0 | 1 (0.2) | 3 (0.7) | 8 (1.9) | |
| Engels et al[5] | 2011 | 37888 | 1563 | 365 (1.0) | NA | NA | 300 (0.8) | 67 (1.8) | NA | NA | NA | NA | 831 (2.2) | |
| Chatrath et al[140] | 2013 | 534 | 80 | 16 (3.0) | 24 (4.5) | 9 (1.7) | 13 (2.4) | 1 (0.2) | 1 (0.2) | 1 (0.2) | NA | 1 (0.2) | 14 (2.6) | |
| Schrem et al[141] | 2013 | 2000 | 120 | 23 (1.1) | NA | 11 (0.5) | 14 (0.7) | 7 (0.3) | 13 (0.6) | 5 (0.2) | 8 (0.4) | 10 (0.5) | 29 (1.4) | |
| Krynitz et al[32] | 2013 | 1221 | 150 | 27 (2.2) | 58 (4.7) | 4 (0.3) | 6 (0.5) | 2 (0.1) | 6 (0.5) | 4 (0.3) | 7 (0.6) | 10 (0.8) | 26 (2.1) | |
| Mouchli et al[62] | 2017 | 373 | 64 | 22 (5.9) | 5 (1.3) | NA | NA | 11 (2.9) | 11 (2.9) | 7 (1.9) | 5 (1.3) | 3 (0.8) | 0 | |
| Egeli et al[142] | 2017 | 429 | 9 | NA | 1 (0.2) | 2 (0.4) | 5 (1.1) | NA | NA | NA | NA | NA | 1 (0.2) | |
| Taborelli et al[143] | 2018 | 2832 | 266 | 37 (1.3) | 72 (2.5) | 34 (1.2) | 28 (1.0) | 4 (0.2) | 21 (0.7) | 2 (0.1) | 4 (0.2) | 3 (0.1) | 65 (2.1) | |
NA: Not available; DNM: De novo malignancy; PTLD: Post-transplant lymphoproliferative disease.