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. 2019 Sep 19;12:221. doi: 10.3389/fnmol.2019.00221

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Copyright © 2019 Hakim, Battle, Belmer, Bartlett, Johnson and Chehrehasa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neural circuitry of olfactory information. Primary olfactory receptor neurons (ORNs) residing in the main olfactory epithelium of the nasal cavity carry information to the olfactory bulb (OB), which is then relayed by the mitral cells to the entorhinal cortex (EC) that sends inputs to the dentate gyrus (DG) and projects back to the OB. Mitral cells also project to the olfactory tubercle (OT), anterior olfactory nucleus (AON), either the medial (MeA), corticomedial (CMe) or basolateral amygdala (BLA) and both the anterior and posterior regions of the piriform cortex (PC). The tufted cells carry olfactory information to the OT, AON and exclusively to the posterior portion of the PC.