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. 2019 Sep 25;9:13848. doi: 10.1038/s41598-019-50124-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evolutionary patterns of miRNA target sites. (a) The number of predicted miRNA target sites. Species-specific target sites are shown in yellow bar and other target sites with different level of conservation are shown in blue bars. (b) Distribution of species-specific miRNA targets in genes. For each gene, the density of species-specific targets was counted based on the length of the 3′ UTR. Some genes at the right tail exhibit extremely high emergence rates of species-specific targets. The top 5% genes were selected for GO enrichment test.