TABLE 3.

MALDI-IMS intensities (expressed as % of the most abundant peak) of molecular species of PC and PA that were found modified in positive ion detection mode in sagittal brain sections from WT (n = 5) compared to the maLPA₁-null (n = 5).

		Cortex		Hippocampus		Striatum		Corpus callosum		Cerebellum
Assignment	m/z	WT	LPA1-null	WT	LPA1-null	WT	LPA1-null	WT	LPA1-null	WT	LPA1-null
GlcCer(d18:1/14:0) + K+	710.4899	14.5 ± 0.8	9.3 ± 1.5∗∗	22.6 ± 1.0	19.1 ± 2.4	22.0 ± 1.3	15.2 ± 2.3∗	14 ± 0.9	11.1 ± 1.7	21.3 ± 2.3	21.1 ± 3.5
PA(16:0/18:1) + K+	713.4535	47.6 ± 2.0	37.3 ± 3.5∗	46.5 ± 2.0	37.2 ± 3.4∗	45.1 ± 2.2	35.3 ± 3.3∗	34.6 ± 2.9	28.9 ± 2.9	34.5 ± 1.1	32.2 ± 4.3
PC(32:0)+	734.5700	20.2 ± 3.2	25.3 ± 7.1	27.1 ± 3.6	17.9 ± 1.7∗	28.1 ± 3.3	26.7 ± 6.1	19.5 ± 3.0	20.9 ± 4.3	21.4 ± 2.2	22.7 ± 4.4
PC(36:1) + K+	826.5733	15.8 ± 0.7	19.6 ± 1.5∗	16.3 ± 0.8	20.4 ± 0.5∗	22.2 ± 1	26.2 ± 0.9∗	37.7 ± 1.1	42.0 ± 3.6	28.1 ± 0.8	28.2 ± 0.9
PC(38:6) + K+	844.5270	10.3 ± 0.7	13.5 ± 1.1∗	8.4 ± 0.4	11.3 ± 1.0∗	8.3 ± 0.6	10.3 ± 1.2	6.5 ± 0.5	8.5 ± 1.6	12.9 ± 1.1	16.1 ± 0.6∗
PC(38:4) + K+	848.5572	8.1 ± 0.9	8.7 ± 1.1	12 ± 0.6	15.7 ± 0.9∗	11.1 ± 0.6	13.2 ± 1.0	8.9 ± 0.4	11.1 ± 1.1	5.3 ± 0.2	6.4 ± 0.4∗

Data are mean ± SEM values. The p-values were calculated by the unpaired two-tailed Student’s t test ^∗p< 0.05, ^∗∗p< 0.01.