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. 2019 Sep 19;9:927. doi: 10.3389/fonc.2019.00927

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Copyright © 2019 Murdocca, Capuano, Pucci, Cicconi, Polidoro, Catini, Martinelli, Paolesse, Orlandi, Mango, Novelli, Di Natale and Sangiuolo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images of murine organs evaluated on H&E sections. Metastasis foci have been evidenced in liver, lung and lymph nodes in mice endovenously injected with scramble_RNAi DLD-1 cells. Metastatic repetitions with mucinous aspect were found in all liver of scramble_RNAi mice (*). Scale bar 20 μm. Quantitative analysis of metastasis number (A) and metastatic area (B) in tissues obtained from mice endovenously injected with scramble_RNAi and LOX-1_RNAi cells. Metastasis number and area are significantly reduced in LOX-1_RNAi injected mice respect to those injected with scramble_RNAi cells. **P < 0.02,*P < 0.05.