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. 2019 Sep 25;9:13903. doi: 10.1038/s41598-019-50444-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Aged Panx1^Δot female mice have increased mechanical properties in cortical bone. Femur cortical bone structural (A) and material (B) mechanical properties were measured by 3-point bending at 4 and 13 months of age female mice. (n = 9–12 per group). Bars represent mean ± s.d., ^#p < 0.05 versus Panx1^fl/fl mice at the same age, *p < 0.05 versus 4-month-old mice of the same genotype, and lines indicate age effect, by 2-way ANOVA.