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. 2019 Sep 13;10:1040. doi: 10.3389/fphar.2019.01040

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Copyright © 2019 Gao, Lv, Long, Chen, He, Ruan and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Butyrate resists the gut flora perturbation of C57BL/6J mice induced by HFD. Fecal samples from both HFD and butyrate group were collected at 4 weeks. Fecal DNA was subjected to 16S rRNA sequencing, and sequences were analyzed using QIIME2 (version 2018.11). (A) Relative abundance of a major microbial phylum in the butyrate and HFD group. Data are mean ± SD (*p < 0.05; Wilcoxon matched-pairs signed rank test and Mann–Whitney U test). (B) Relative abundance of a major microbial family in the butyrate and HFD group. The seven abundant families are shown. Data are mean ± SD (*p < 0.05; Wilcoxon matched-pairs signed rank test and Mann–Whitney U test). (C) The ratio of the major microbial family/phylum in the butyrate and HFD group. Data are mean ± SD (*p < 0.05; Wilcoxon matched-pairs signed rank test and Mann–Whitney U test).