Figure 2.
HFD changes metabolic profiles in C57BL/6J mice. Blood samples were collected at week 4. Serum metabolomics analysis was performed with the pairwise method on the XCMS online platform. (A) Differential featured plots were shown. Only dysregulated features (p-value ≤ 0.05 and fold change ≥ 1.5) are displayed. Up-regulated features are shown in green, and down-regulated features are shown in red. (B) PCoA of the features intensities from all simples. The control group is shown in red; the HFD group is shown in blue; the quality control is shown in green (C) PLS-DA scores plot of the control and HFD group. Blue spots represent the control group, and the red spots represent the HFD group. (D) The red column represents up-regulated metabolites, and green column represents down-regulated metabolites in the HFD group.