Yang 2008.

Methods	RCT, parallel design
Participants	Total number of randomized participants: 102 Inclusion criteria: non‐cardiac surgery (major abdominal) with risk or at high risk of coronary artery disease Exclusion criteria: chronic metoprolol use Type of surgery: non‐cardiac surgery (major abdominal) Baseline characteristics Intervention group (metoprolol) Age, mean (SD): 71 (± 8) years Gender, M/F: 21/30 Control group (standard care) Age, mean (SD): 71 (± 9) years Gender, M/F: 21/30 Country: China Setting: single centre; hospital
Interventions	Intervention group (metoprolol) Randomized, n = 51; losses = 0; analysed, n = 51 (not reported whether ITT analysis was used) Details: metoprolol given orally or intravenously, and titrated to BP and HR; treatment was started 2 h before surgery and was continued until 30 days after surgery Control group (standard care) Randomized, n = 51; losses = 0; analysed, n = 51 (not reported whether ITT analysis was used) Details: standard care
Outcomes	Outcomes measured/reported by study authors: changes in HR, levels of creatine kinase (CK‐MB), mortality, acute MI, stroke Outcomes relevant to the review: mortality, acute MI, stroke
Notes	Funding/declarations of interest: not reported Study dates: January 2006‐October 2007 Chinese study reported translated with the help of Dr Y Wang (Acknowledgements)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not specified
Allocation concealment (selection bias)	Unclear risk	Not specified
Blinding of participants and personnel (performance bias) All outcomes	High risk	Open‐label trial
Blinding of outcome assessors (detection bias) All outcomes	High risk	Open‐label trial
Incomplete outcome data (attrition bias) All outcomes	Low risk	No apparent losses
Selective reporting (reporting bias)	Unclear risk	Study authors did not report prospective clinical trial registration or publication of a protocol. It was not feasible to effectively assess risk of reporting bias
Other bias	Low risk	Not detected