EUCTR2010‐021844‐17.

Trial name or title	Perioperative esmolol infusion for haemodynamic stability during major vascular surgery
Methods	RCT, parallel design
Participants	Estimated number of recruited participants: 260 Inclusion criteria: scheduled for arterial vascular surgery, including AAA repair, abdominal aortic stenosis surgery, lower limb arterial reconstruction or carotid artery stenosis repair Exclusion criteria: active bleeding; untreated left main disease; active cardiac condition; preoperative positive troponin T; contraindication to esmolol use; previous allergy or intolerance to esmolol; cancer with life expectancy < 6 months; excessive alcohol use; pregnancy or planning to become pregnant; failure to provide informed consent; failure to monitor HR with continuous 12‐lead ECG because of surgery or baseline ECG abnormalities Country: Netherlands Setting: hospital; single centre
Interventions	Esmolol hydrochloride IV Placebo
Outcomes	Outcomes measured/reported by study authors: haemodynamic stability; myocardial ischaemia; TIA or stroke; bradycardia Outcomes relevant to the review: TIA or stroke; bradycardia
Starting date	Unknown, registered in July 2010
Contact information	Erasmus Medical Centre
Notes