FIG 7.

Mutation substitutions cluster according to cross-resistance clades. (a to d) Front, back, top, and bottom views, respectively, of an I-TASSER-predicted structure of M. tuberculosis MmpL3 based on M. smegmatis MmpL3 structure (PDB code 6AJH). Substitutions conferred by mutations in mmpL3 are indicated. Substitutions are colored based on clade from cross-resistance profiling as follows: green, clade I substitutions; red, clade II substitutions; blue, M649, which fell into both clades depending on the substitution. The model shows a truncated version (732/944 aa) of the MmpL3 protein lacking the C-terminal tail.