TABLE 1.
Carbapenem complexes of OXA enzymes
| Carbapenem | Enzyme | Source | Resolution (Å) | Bridge | Tautomer | PDB accession no. |
|---|---|---|---|---|---|---|
| Imipenem | OXA-13 | Pseudomonas aeruginosa | 1.9 | Noa | Δ2 | 1H5X |
| OXA-23b | A. baumannii | 1.5 | No | Δ1R | 6N6U | |
| OXA-23c | A. baumannii | 3.3 | No | Δ1R | 6N6X | |
| OXA-48 | K. pneumoniae | 1.95 | Noa | Δ2 | 5QB4 | |
| OXA-48 | K. pneumoniae | 1.8 | Noa | Δ2 | This work | |
| OXA-239d | A. baumannii | 1.87 | Yes | Δ1R | 5WIB | |
| Meropenem | OXA-13 | P. aeruginosa | 2.0 | Noa | Δ2 | 1H8Y |
| OXA-23 | A. baumannii | 2.14 | Yes | Δ1S | 4JF4 | |
| OXA-23b | A. baumannii | 1.5 | No | Δ1R | 6N6V | |
| OXA-23c | A. baumannii | 3.5 | No | Δ1R | 6N6Y | |
| OXA-48 | K. pneumoniae | 1.75 | Noa | Δ2 | This work | |
| Ertapenem | OXA-48 | K. pneumoniae | 2.35 | Noa | Δ2 | This work |
| Doripenem | OXA-1 | E. coli | 1.4 | No | Δ1R | 3ISG |
| OXA-24/40 | A. baumannii | 2.25 | Yes | Δ2 | 3PAG | |
| OXA-24/40 | A. baumannii | 2.1 | Yes | Δ2 | 3PAE | |
| OXA-48 | K. pneumoniae | 1.9 | Noa | Δ2 | This work | |
| OXA-51e | A. baumannii | 1.77 | Yes | Δ2 | 5L2F | |
| OXA-239f | A. baumannii | 1.86 | Yes | Δ2 | 5WI7 |
a
Both OXA-13 and OXA-48 have what is now defined as a pseudobridge rather than the classical hydrophobic bridge seen in the A. baumannii CHDLs.
b
Bridge-deficient mutant, low-pH complex.
c
Bridge-deficient mutant, neutral-pH complex.
d
The imipenem has no tail (truncated at the sulfur) in one molecule in the asymmetric unit.
e
The bridge residues are Phe111 and Trp222.
f
The doripenem is truncated after the pyrrolidine ring in one molecule in the asymmetric unit.