FIG 1.

Dose-response curves for delafloxacin against 12 K. pneumoniae strains (A) and 5 P. aeruginosa strains (B) in the neutropenic murine lung infection model. Symbols represents means and standard deviations from three lung infection replicates. Gray symbols, strains retrieved from our previous study (8). Eight different dose levels were administered by subcutaneous route every 6 h. The burden of organisms was enumerated at the start and end of therapy over a 24-h study period. Horizontal dashed line at 0, burden of organisms at the start of therapy. Data points above the line, net growth (i.e., increase) in burden; data points below the line, reduction in bacterial burden.