TABLE 2.

Delafloxacin pharmacodynamic target exposures for each K. pneumoniae and P. aeruginosa strain in the murine lung infection model

Organism and strain	Bacterial burden at start of therapy (log10 CFU/lung)	Growth in control at 24 h (Δlog10CFU/lung)	Stasis			1-Log kill
			Dose (mg/kg/24 h)	24-h AUC/MIC		Dose (mg/kg/24 h)	24-h AUC/MIC
				Total drug	Free drug		Total drug	Free drug
K. pneumoniae
43816a	6.30	2.86	304	5,287	127
4105a	6.30	3.33	106	128	3.08	196	228	5.47
4110a	6.32	2.82	NAb
81-1260Aa	6.28	2.83	84.8	1,681	40.3	238	4,369	105
1037570	6.53	2.95	NA
997613	6.56	3.04	NA
1002059	6.64	3.05	639	1,192	28.6
993043	6.99	2.39	134	1,365	32.8	545	4,312	103
1004234	6.64	2.70	50.7	952	22.8	862	13,394	321
1008721	6.71	2.37	157	6,467	155
1009343	6.92	2.76	109	528	12.7	233	1,032	24.8
1014490	7.26	2.72	37.2	161	3.87	98.5	474	11.4
Median			109	1,192	28.6	235	2,672	64.1
SE			63.0	764	18.3	117	2,033	48.8
P. aeruginosa
71	6.23	2.36	294	309	7.41	830	774	18.6
62	6.92	3.81	354	179	4.30	903	421	10.1
65	6.93	3.64	1,057	236	5.66	NA
724	6.31	3.57	107	1,035	24.8	246	2,152	51.6
1004586	6.52	3.11	61.5	142	3.41	169	409	9.82
Median			294	236	5.66	538	598	14.3
SE			179	166	3.99	192	413	9.91

^aThe results for these strains were retrieved from our previous study (8).

^bNA, not achieved.