TABLE 2.
Effects of monotherapy and combined therapy on the clearance of strains from mouse lungs
| A. baumannii strain | Bacterial load (mean log10CFU/g lung ± SEM) |
Decrease in bacterial load compared with that of nontreated mice (log10CFU/g lung) |
|||
|---|---|---|---|---|---|
| Nontreated | Imipenem | Imipenem + LN-1-255 | Imipenem | Imipenem + LN-1-255 | |
| ATCC 17978 + pET-RA/OXA-23 | 10.6 ± 4.5 | 9.1 ± 2.4 | 6.6 ± 1.4 | 1.5 | 4.0 |
| Ab1 (OXA-23) | 10.3 ± 1.8 | 9.6 ± 2.6 | 8.6 ± 2.1 | 0.7 | 1.7 |
| ATCC 17978 + pET-RA/OXA-24/40 | 10.0 ± 2.3 | 9.2 ± 3.1 | 7.5 ± 1.8 | 0.8 | 2.5 |
| JC12/04 (OXA-24/40) | 10.7 ± 1.9 | 10.2 ± 3.6 | 6.2 ± 1.7 | 0.5 | 4.5 |