TABLE 5.
Urine recovery of FEP and TAZ
| Drug, period,a and statistic | Mild |
Moderate |
Severe |
|||
|---|---|---|---|---|---|---|
| Impairment (n = 6) | Control (n = 6) | Impairment (n = 5) | Control (n = 6) | Impairment (n = 6) | Control (n = 6) | |
| FEP | ||||||
| 0–2 h | ||||||
| Mean | 620.8 | 730.5 | 308.4 | 762.9 | ||
| SD | 191.0 | 164.4 | 252.0 | 159.4 | ||
| 0–4 h | ||||||
| Mean | 1,198.4 | 1,354.1 | 659.2 | 1,446.0 | ||
| SD | 471.1 | 243.9 | 362.3 | 183.6 | ||
| 0–8 h | ||||||
| Mean | 1,666.5 | 1,816.9 | 1,047.5 | 1,773.9 | ||
| SD | 539.0 | 262.0 | 419.3 | 272.4 | ||
| 0–12 h | ||||||
| Mean | 1,848.8 | 1,962.4 | 1,295.5 | 1,865.7 | ||
| SD | 576.4 | 301.3 | 541.3 | 301.2 | ||
| 0–24 h | ||||||
| Mean | 1,977.6 | 2,030.4 | 1,524.5 | 1,914.8 | 359.1 | 1,950.2 |
| SD | 560.4 | 330.4 | 559.7 | 308.3 | 99.3 | 276.1 |
| 0–48 h | ||||||
| Mean | 1,981.1 | 2,030.4 | 1,562.8 | 1,914.8 | 438.7 | 1,950.2 |
| SD | 563.0 | 330.4 | 563.3 | 308.3 | 102.6 | 276.1 |
| TAZ | ||||||
| 0–2 h | ||||||
| Mean | 1,053.1 | 1,086.6 | 557.8 | 1,168.9 | ||
| SD | 279.0 | 255.1 | 321.9 | 221.3 | ||
| 0–4 h | ||||||
| Mean | 1,656.7 | 1,558.3 | 1,021.2 | 1,683.7 | ||
| SD | 575.0 | 219.7 | 403.0 | 258.6 | ||
| 0–8 h | ||||||
| Mean | 1,874.6 | 1,778.2 | 1,293.0 | 1,776.6 | ||
| SD | 622.3 | 269.6 | 408.0 | 269.3 | ||
| 0–12 h | ||||||
| Mean | 1,907.2 | 1,791.0 | 1,365.1 | 1,776.6 | ||
| SD | 639.3 | 291.0 | 412.9 | 269.3 | ||
| 0–24 h | ||||||
| Mean | 1,907.2 | 1,791.0 | 1,365.1 | 1,776.6 | 296.1 | 1,842.9 |
| SD | 639.3 | 291.0 | 412.9 | 269.3 | 53.2 | 174.8 |
| 0–48 h | ||||||
| Mean | 1,907.2 | 1,791.0 | 1,365.1 | 1,776.6 | 296.1 | 1,842.9 |
| SD | 639.3 | 291.0 | 412.9 | 269.3 | 53.2 | 174.8 |
a
Postdose times are indicated.