TABLE 3.

Association between antecedent carbapenem exposure and the occurrence of carbapenem-resistant Enterobacteriaceae stratified by species and carbapenemase types^a

Stratified analyses by comparison	Multivariate analysisb aOR (95% CI)
NCPCR K. pneumoniae vs CP K. pneumoniaec	5.34 (2.96–9.64)
NCPCR E. coli vs CP E. colid	5.58 (2.37–13.15)
NCPCRE vs KPC-producing Enterobacteriaceaee	7.04 (3.55–13.99)
NCPCRE vs NDM-producing Enterobacteriaceaef	3.74 (2.31–6.05)

^aAbbreviations: NCPCR, non-carbapenemase-producing carbapenem-resistant; CP, carbapenemase-producing; NCPCRE, non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae; KPC, Klebsiella pneumoniae carbapenemase; NDM, New Delhi metallo-beta-lactamase.

^bRandom effect logistic regression model allowing for clustering within hospitals and adjusted for month of CRE sample collection. Note: carbapenemase-producing organisms (CP K. pneumoniae, CP E. coli, KPE-producing Enterobacteriaceae, NDM-producing Enterobacteriaceae) are the base group for odds ratio calculations. All comparisons have P values of <0.001.

^cDetails of univariate and multivariate analyses are available in Table S2.

^dDetails of univariate and multivariate analyses are available in Table S3.

^eDetails of univariate and multivariate analyses are available in Table S4.

^fDetails of univariate and multivariate analyses are available in Table S5.