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Mean DLM and DM-6705 concentrations in rabbit CSF and brain tissuea
| Infection category | Time (h) | Mean concn (ng/ml) |
|||
|---|---|---|---|---|---|
| DLM in CSF | DM-6705 in CSF | DLM in brain tissue | DM-6705 in brain tissue | ||
| Uninfected | 9 | 0.49 | 0 | 488 | 160 |
| Uninfected | 24 | 0.27 | 0 | 96 | 286 |
| Infected | 9 | 2.04 | 0.28 | 549 | 425 |
| Infected | 24 | 0.67 | 0.75 | 52 | 221 |
Data are for 2 uninfected rabbits euthanized at 24 h, 2 infected rabbits euthanized at 9 h, 1 uninfected rabbit euthanized at 9 h, and 1 infected rabbit euthanized at 24 h.
