TABLE 2.
Susceptibility of Staphylococcus species to exebacase and comparator antibioticsa
| Organism | n | Exebacase |
DAP |
VAN |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC50a | MIC90 | Range | MIC50 | MIC90 | Range | MIC50 | MIC90 | Range | ||
| S. aureus (MSSA) | 73 | 0.5 | 0.5 | 0.25–1 | 0.25 | 0.25 | 0.125–0.5 | 1 | 1 | 0.5–1 |
| S. aureus (MRSA) | 74 | 0.5 | 1 | 0.5–2 | 0.25 | 0.5 | 0.125–1 | 1 | 1 | 1–2 |
| S. epidermidisb | 52 | 0.5 | 0.5 | 0.125–2 | ND | ND | ND | ND | ND | ND |
| S. lugdunensis | 46 | 1 | 1 | 0.25–2 | 0.5 | 1 | 0.25–2 | 1 | 1 | 0.5–2 |
| S. haemolyticus | 34 | 0.5 | 1 | 0.25–2 | 0.5 | 1 | 0.25–2 | 1 | 2 | 0.5–4 |
| S. capitis | 13 | 1 | 2 | 0.25–4 | 0.5 | 1 | 0.25–1 | 1 | 1 | 0.5–2 |
| S. warneri | 21 | 0.5 | 1 | 0.06–1 | 0.5 | 2 | 0.25–2 | 1 | 2 | 0.25–2 |
a
MIC values are indicated in μg/ml. DAP, daptomycin; VAN, vancomycin.
b
MIC values for DAP and VAN data were not determined (ND) for S. epidermidis.