Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The pyrimidinetrione amide lacks in vivo efficacy. (A) PK profile of compound 10 after twice-daily administration at 30 mg/kg. (B) M. tuberculosis bacterial burdens in infected mice after 2 and 4 weeks of once-daily or twice-daily treatment at 30 and 15 mg/kg, respectively. Treatment was initiated at 2 weeks after aerosol infection of the mice. The error bars indicate SD. Q, once daily; B, twice daily.
