TABLE 1.
MICs of 1H-benzo[d]imidazole derivatives EJMCh4 and EJMCh6 against wild-type M. tuberculosis H37Rv and resistant mutants
| Compound and strain (mutation)a | MIC50 (μM) | MIC90 (μM) |
|---|---|---|
| EJMCh4 | ||
| H37Rv | 1.22 | 2.44 |
| MmpL3 mutants | ||
| 4/1 (V285A) | 13.00 | 19.50 |
| 4/3 (V195A) | 6.50 | 13.00 |
| EJMCh6 | ||
| H37Rv | 0.029 | 0.145 |
| MmpL3 mutants | ||
| 6A (V684A) | 0.77 | 1.93 |
| 6B (V240A) | 0.77 | 1.93 |
| 6C (G253E) | 0.77 | 1.93 |
a
The 4/1 and 4/3 mutants were selected in the presence of compound EJMCh4 at 2.44 μM. The 6A, 6B, and 6C mutants were selected in the presence of compound EJMCh6 at 0.145 μM.