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IC50 values for DBO inhibitors against class A β-lactamasesa
| Protein | IC50 values (nM) by inhibitor |
|
|---|---|---|
| Avibactam | Relebactam | |
| CTX-M-15 | 3.4 (0.02) | 400 (0.04) |
| L2 | 15 (0.02) | 470 (0.03) |
| KPC-2 | 10 (0.05) | 230 (0.03) |
| KPC-3 | 29 (0.03) | 260 (0.05) |
| KPC-4 | 9.3 (0.08) | 910 (0.03) |
Standard errors of log IC50 values are shown in parentheses.
