TABLE 5.
In vitro evolution of drug resistance in T. rubrum following exposure to subinhibitory drug concentrations for 5 or 10 transfers before selection
| Strain and no. of transfers | Resistance frequencya
|
|
|---|---|---|
| Efinaconazole | Ciclopirox | |
| ATCC 28188 | ||
| 5 | 7.21 × 10-8 | <5.24 × 10-9 |
| 10 | 6.92 × 10-7 | <6.75 × 10-10 |
| ATCC MYA-4438 | ||
| 5 | 1.7 × 10-8 | <2 × 10-9 |
| 10 | 1.25 × 10-7 | <1.62 × 10-9 |
| CI-1 | ||
| 5 | <9.8 × 10-8 | <4.4 × 10-9 |
| 10 | 1.2 × 10-8 | <2.75 × 10-9 |
| CI-2 | ||
| 5 | 9.37 × 10-9 | <5 × 10-8 |
| 10 | 2.18 × 10-7 | <1.19 × 10-8 |
a
Resistance frequency data were calculated by dividing the number of CFU grown on the plates containing each drug by the total number of CFU spread on plates.