TABLE 1.
Summary of final model parameters
| Parameter | QTcN estimate (90% CI) | QTcF estimate (90% CI) | QTcB estimate (90% CI) |
|---|---|---|---|
| Slopepretomanid [ms/(μg/ml)] | 1.61 (1.28, 1.94) | 1.54 (1.21, 1.88) | 1.53 (1.18, 1.88) |
| SlopeM2 [ms/(μg/ml)] | 19.3 (15.2, 23.3) | 18.3 (14.1, 22.4) | 19.6 (15.2, 24) |
| Slopemoxifloxacin [ms/(μg/ml)] | 2.60 (1.66, 3.54) | 2.47 (1.52, 3.41) | 2.77 (1.77, 3.76) |
| Slopebaselinea | –0.305 (–0.342, –0.268) | –0.362 (–0.397, –0.327) | –0.251 (–0.288, –0.214) |
| SD of the residual error, ε (ms) | 10.2 (10.1, 10.4) | 10.4 (10.2, 10.6) | 10.8 (10.6, 11.1) |
| SD of the random effect of the intercept, η (ms) | 9.58 (9.06, 10.1) | 9.39 (8.88, 9.94) | 10.5 (9.95, 11.1) |
a
The median baseline QTcN was 405 ms, that of QTcF was 390 ms, and that of QTcB was 415 ms.