Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model-predicted ΔΔQTcN and ΔQTcN in subjects treated with pretomanid alone
| Parameter | Value at indicated dose (mg) |
||
|---|---|---|---|
| 100 | 200 | 400 | |
| Cmax,ss (μg/ml)a | 1.6 | 3.2 | 6.2 |
| Concn-driven response | |||
| ΔΔQTcN (ms) mean | 2.6 | 5.1 | 9.9 |
| ΔΔQTcN (ms) upper limit of 90% CI | 3.2 | 6.2 | 12.0 |
| Concn-driven response + maximum secular trend (4.0 ms) | |||
| ΔQTcN (ms) mean | 6.6 | 9.1 | 13.9 |
| ΔQTcN (ms) upper limit of 90% CI | 7.2 | 10.2 | 16.0 |
Maximum pretomanid concentration at steady state of a typical DS-TB subject.
