FIG 1.

Final compartmental model for plasma and fecal moxifloxacin pharmacokinetics (red) and for bacterial diversity indices (orange). k_tr is the transfer rate between each compartment for the absorption delay; k_a is the absorption rate to the central compartment; k_e is the extraintestinal elimination rate from the central compartment; k₁₂ and k₂₁ are the transfer rates between the central compartment and the peripheral compartment; k_ct1 is the elimination rate from the central compartment to the intestinal tract; k_fc is the transfer rate between the lower gastrointestinal tract and the central compartment; k_t is the transfer rate between the intestinal transit compartments; k_f is the elimination rate from the lower gastrointestinal tract; R_in is the zero-order constant for production of the diversity index; k_out is the first-order elimination rate of the diversity index from the lower gastrointestinal tract. C_f is the concentration in the feces; E_max is the maximal effect of moxifloxacin on the elimination rate of the diversity index; and EC₅₀ is the concentration of moxifloxacin leading to 50% of the maximal effect. Data were available for the 3 compartments with bold boxes. GIT, gastrointestinal tract.