TABLE 1.
Measures of the impact of moxifloxacin on gut microbiome diversitya
| Pharmacodynamic index | Shannon index (median [min, max]) | No. of OTUs (median [min, max]) |
|---|---|---|
| Time to maximal loss (days) | 7.0 (5.1, 11.4) | 8.5 (5.5, 13.8) |
| Maximal loss | 1.2 (0.8, 1.3)b | 77 (47, 100)c |
| Maximal loss (% of baseline value) | 27.5 (17.5, 27.7) | 47.4 (30.4, 48.3) |
| Time to return to 95% of baseline value (days) | 16.3 (8.7, 25.3) | 21.3 (13.3, 30.4) |
| AUC between day 0 and day 42 of the change of diversity indices from day 0 | −16.7 (−28.7, −5.2)d | −1,084 (−2,323, −378)e |
a
Derived from the estimated individual pharmacodynamic parameters in the 14 treated individuals.
b
Shannon units.
c
No. of OTUs.
d
Units/day.
e
No. of OTUs/day.