FIG 1.
Regulation mechanism between LuxS/AI-2 and bacterial resistance. Abbreviations: AI-2 autoinducer-2; LuxS, AI-2 synthase; LrsC, response regulator; MetF, 5,10-methylenetetrahydrofolate reductase; MetE, methionine synthase; MetH, B12-dependent homocysteine-5-methyltetrahydrofolate methyltransferase; THF, tetrahydrofolate; GlyA, serine hydroxymethyltransferase; ThyA, thymidylate synthase; AICAR, 5-aminoimidazole-4-carboxamine ribonucleotide; DHF, dihydrofolate; FolC, dihydrofolate synthase; FolA, dihydrofolate reductase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; Pfs, S-adenosylhomocysteine nucleosidase; SRH, S-ribosylhomocysteine; LuxS, S-ribosylhomocysteinase; DPD, 4,5-dihydroxy-2,3-pentanedione (the precursor of AI-2).