TABLE 2.
Overview of LuxS/AI-2 QS inhibition strategies
| Inhibitor | Action mode | Biological effect | Reference |
|---|---|---|---|
| Inhibition target: signal generators | |||
| MT-DADMe-ImmA (transition state analog) | Pfs inhibitor | Inhibit AI-2 production | 73 |
| Hydroxylated pyrrolidines derivatives |
Inhibitors of SAH/MTA nucleosidase. |
Inhibit AI-2 production | 76 |
| TNRHNPHHLHHV (peptide) | Interact with the LuxS enzyme | Inhibit enzyme activity | 86 |
| Inhibition target: signal molecule | |||
| Ex vivo addition of LsrK and ATP | Phosphorylation and degradation of AI-2 | Inhibits bioluminescence in V. harveyi and lsr expression in E. coli and S.Typhimurium | 90 |
| Imidazole | A furan carbocyclic analog of AI-2 | Inhibiting AI-2 function | 93 |
| Inhibition target: signal receptor/transduction | |||
| d-Galactose | Inhibitor AI-2 activity | Targeting AI-2 activity for prevention biofilm formation. | 99 |
| Small peptide, 5906 | Prevents LuxS homodimer formation | Inhibits LuxS activity by binding specifically to LuxS | 100 |