TABLE 1.
Prevalence of NS-SNPs in the K13 propeller domain before and after the introduction of ACTsa
| Site | Prevalence (%) |
P | Polymorphism(s) |
||
|---|---|---|---|---|---|
| Pre-ACTs (1999–2004) | Post-ACTs (2012–2016) | Pre-ACTs | Post-ACTs | ||
| Apac | 2/100 (2.0) | 0/19 (0.0) | 1.00 | K610E, P615N | |
| Arua | 4/86 (4.7) | 2/40 (5.0) | 1.00 | V555A, A578S, N594K, L618S | W470R, A675V, A578S |
| Jinja | 1/99 (1.0) | 3/99 (3.0) | 0.62 | V581I | K563E, A578S x2 |
| Kampala | 2/100 (2.0) | 2/65 (3.1) | 0.65 | V555A x2 | S522C, A578S |
| Kanungu | 0/100 (0.0) | 5/118 (4.2) | 0.06 | I540T x2, G533A x2, V555A | |
| Mubende | 5/99 (5.0) | 2/66 (3.0) | 0.70 | G496S, V555A, E567K, A578S x2 | C469Y, P574L |
| Tororo | 2/99 (2.0) | 12/303 (3.9) | 0.53 | L457I, W565R | I465T and L619S, C469F, M472V, Y558H, A569T, A569S, A578S x4, N594K, A617T |
| Total | 16/683 (2.3) | 26/716 (3.6) | 0.16 | ||
a
Isolates with mixed genotypes are considered mutant. Prevalences (i.e., the number of NS-SNPs/total SNPs) were compared using Fisher exact tests, and P values were considered significant if P < 0.05.