Figure EV6. Geminin‐mCherry reporter tracks the level of cell cycle arrest in response to p53 amplitude and duration modulation.

• A
  Representative phase contrast, red fluorescence (indicating geminin‐mCherry levels), and yellow fluorescence (indicating p53‐Venus levels) images of cells in response to the “natural dynamics” Nutlin‐3 dosing regimen over 40 h.
• B, C
  Percentage of cells undergoing cell division within the 40 h of imaging in response to amplitude modulation (B) or duration modulation (C) Nutlin‐3 dosing regimens. N = at least 102 cells per condition.