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. 2019 Sep 17;30(9):1133–1146. doi: 10.1089/hum.2019.016

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© Carolina Petrillo et al., 2019; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — CsA also improves transduction in brain-repopulating myeloid progenitors. BM-CD34⁺ cells were transduced with SINLV PGK-GFP at a MOI of 10 with or without CsA and were then transplanted into NSG mice. (A) Brain analysis of the mice was performed at sacrifice 17 weeks post transplant, as reported in the scheme. (B) Percentages of human CD45⁺ over the total cells were evaluated. (C) Percentages of human myeloid cell lineages (hCD11b⁺) within human CD45⁺ cells are shown. (D) VCN from colony-forming units 15 days after plating are reported. (E) Transduction levels were evaluated as percentage of GFP⁺ cells with FACS. Data represent the mean ± SD, n ≥ 4 mice per group, Mann–Whitney test.