Table 3. Percent Growth Inhibitions of MRSA and MSSA in the Presence of Subinhibitory Concentrations of VA, 2-HCA, and Vancomycin (Van) and the Confirmation of Minimum Inhibitory Concentrations at Each Transfera,b.
| % growth inhibitions
of bacteria |
||||
|---|---|---|---|---|
| initial | 1st increment | 2nd increment | final | |
| MRSA | ||||
| subinhibitory [VA] | 35 ± 4.5 | 43 ± 1.4 | 46 ± 1.6 | 36 ± 11.6 |
| MIC (2.5 mg/mL) VA | NC | NC | NC | NC |
| subinhibitory [2-HCA] | 46 ± 3.1 | 53 ± 2.6 | 52 ± 14 | 75 ± 15 |
| MIC (1.6 mg/mL) 2-HCA | NC | NC | NC | NC |
| subinhibitory [van] | 72 ± 6.5 | –19 ± 8.1 | –18 ± 19 | 2 ± 17 |
| MIC (0.01 mg/mL) van | NC | >1.5 fold MIC | =2 fold MIC | =1.5 fold MIC |
| MSSA | ||||
| subinhibitory [VA] | 31 ± 6.0 | 59 ± 5.3 | 69 ± 0.1 | 45 ± 9.5 |
| MIC (2.5 mg/mL) VA | NC | NC | NC | NC |
| Subinhibitory [2-HCA] | 46 ± 14.8 | 66 ± 7.5 | 75 ± 8.5 | 55 ± 7.3 |
| MIC (1.6 mg/mL) 2-HCA | NC | NC | NC | NC |
| subinhibitory [van] | 57 ± 4.2 | 25 ± 14.2 | 31 ± 4.4 | 8 ± 4.3 |
| MIC (0.01 mg/mL) van | NC | >1.5 fold MIC | >2 fold MIC | =2.5 fold MIC |
a
Data represents the mean (±SD) of two independent experiments.
b
NC: not changed.