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. 2019 Jul 17;8(15):e012273. doi: 10.1161/JAHA.119.012273

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sustained In vivo or acute in vitro sildenafil treatment is sufficient to rescue adrenergic response in diabetic adult ventriculomyocytes (AVMs). A, Contractility, (B) calcium transient amplitude, and (C) calcium transient halftime recovery (tau) of AVMs from wild‐type mice fed normal chow (NC) or high fat diet (HFD) for 4.5 months and gavaged with either sildenafil or vehicle only for 1 month. n≥20 cells per group. (D) Contractility, (E) calcium transient amplitude, and (F) calcium transient halftime recovery in isolated adult cardiomyocytes from young 8‐week‐old mice. n≥15 cells per group. For all graphs, *P≤0.05, **P≤0.01, ***P≤0.001, and ****P≤0.0001 by 1‐way ANOVA and Tukey post‐test.