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. 2019 Jul 17;8(15):e012273. doi: 10.1161/JAHA.119.012273

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Inhibition of phosphodiesterase 5 (PDE5) by sildenafil improves contractility in a β2 adrenergic receptor (β₂ AR)–dependent mechanism (A) depiction of the pathway sildenafil uses in mice fed a high fat diet to improve function. CaMKII indicates calcium/calmodulin kinase II; G_i, inhibitory G protein; G_s, stimulatory G protein; PKA, protein kinase A; PKG, protein kinase G; PDE3, phosphodiesterase 3; β₁AR, β1 adrenergic receptor.