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. 2019 Jul 17;8(15):e011012. doi: 10.1161/JAHA.118.011012

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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CardioGRKO male and female mice develop spontaneous left ventricular remodeling. A, Representative images of intact hearts from 6‐month‐old male and female control and cardioGRKO mice. B, Longitudinal hematoxylin & eosin‐stained heart sections from 6‐month‐old male and female control and cardioGRKO mice. Arrows (→) point out to increased left ventricle size and the presence of a thrombus in the left atria of the female cardioGRKO heart. The images are representative of 5 mice per group. CardioGRKO indicates cardiomyocyte‐specific glucocorticoid receptor knockout.