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. 2019 Jul 17;8(15):e011012. doi: 10.1161/JAHA.118.011012

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Genes associated with cardiomyocyte contraction, structure of cardiac sarcomeres, and cardiomyocyte viability are dysregulated in male cardiomyocyte‐specific glucocorticoid receptor knockout (cardioGRKO) hearts but not in their female counterparts. Total RNA was isolated from whole hearts of 3‐month‐old male and female control (glucocorticoid receptor flox/flox) and cardioGRKO mice. A, Expression levels of genes involved in calcium handling ryanodine receptor (Ryr2) and ATPase sarcoplasmic/endoplasmic reticulum Ca²⁺ (Atp2a2). B, Expression levels of genes involved in preserving the structure of cardiac sarcomeres desmin (Des) and troponin C1 (Tnnc1). C, Expression level of Slc25a4 (solute carrier family 25 member 4), a mitochondria carrier protein involved in cardiomyocyte viability. Data are mean±SEM (n=4–5 mice per group). *P<0.05, and **P<0.01. CardioGRKO indicates cardiomyocyte‐specific glucocorticoid receptor knockout.