Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 19;8(15):e012941. doi: 10.1161/JAHA.119.012941

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Function and phenotype analysis of cardiac and noncardiac TF targets. A, A network showing genes in the transforming growth factor β signaling. In left panel, 17 genes of module 4 were in this pathway, with overrepresentation P=1.91e‐09. Node and edge connections in right panel represent adjacencies between a TF and its targets, 12 genes targeted by Id3 and 7 genes for Pitx2. B, The number of enriched pathways (y‐axis) under the regulations of cardiac, literature‐based cardiac, and noncardiac TFs. C, Predicted regulations of cardiac, literature‐based cardiac, and noncardiac TFs in 20 representative heart terms enriched in the selected weighted gene co‐expression network analysis modules. The colors in the heat‐map show the TF‐driver scores in functional terms, representing the regulatory effects of individual TFs on the terms. D, Predicted functional roles of literature‐based cardiac and noncardiac TFs in different heart phenotype‐ or disease‐associated gene sets, with the colors for TF‐driver scores. TF indicates transcription factor.